Cart
sales@molnova.com
BI-9321 trihydrochloride
CAS No. 2387510-87-2
BI-9321 trihydrochloride( —— )
Catalog No. M32809 CAS No. 2387510-87-2
BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 68 | Get Quote |
|
| 5MG | 101 | Get Quote |
|
| 10MG | 180 | Get Quote |
|
| 25MG | 342 | Get Quote |
|
| 50MG | 579 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBI-9321 trihydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionBI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
-
DescriptionBI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of theNSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHistone Methyltransferase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2387510-87-2
-
Formula Weight469.81
-
Molecular FormulaC22H24Cl3FN4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (532.13 mM; Ultrasonic ) H2O : 25 mg/mL (53.21 mM; Ultrasonic)
-
SMILESCl.Cl.Cl.Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccnc2cc(F)ccc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. B?ttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15(8):822-829.?
molnova catalog
related products
-
ciscis-Muconic acid
ciscis-Muconic acid is a naturally-occurring organic acid. It is used in the manufacture of several widely-used consumer plastics. Its microbial production via extending the shikimate pathway has been reported.
-
S-(5-Adenosyl)-L-met...
S-(5'-Adenosyl)-L-methionine chloride is a natural product. S-(5'-Adenosyl)-L-methionine chloride can be used as a reference standard.
-
Methyclothiazide
Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
